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The Department of Neurosurgery
is actively involved in basic science and clinical research.
Below we have provided links to many of our recent publications.
Charalambous C, Hofman FM, Chen TC. Functional
and phenotypic differences between glioblastoma-derived and
normal human brain endothelial cells. J Neurosurg 102(4):699-705,
2005.
Schmitmeier S, Markland FS, Schonthal AH, Chen TC. Potent
mimicry of fibronectin-induced signaling in glioma cells by
the homodimeric snake venom disintegrin contortrostatin.
Neurosurgery 57(1): 141-53, 2005.
Tai CK, Wang WJ, Chen TC, Kasahara N. Single-shot,
multicycle suicide gene therapy by replication-competent retrovirus
vectors achieves long-term survival benefit in experimental
glioma. Molecular Therapy 12: 842-851, 2005.
Khardosh A, Wang W, Chen TC, Schonthal A. Dimethyl-celecoxib
(DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory
function, potently mimics the anti-tumor effects of celecoxib
on Burkitt’s lymphoma in vitro and in vivo, Cancer
Biology & Therapy, 4(5):571-82, 2005.
Pyrko P, Wang W, Markland FS, Swenson SD, Schmitmeier S,
Schonthal AH, Chen TC. The
role of contortrostatin, a snake venom disintegrin, in the
inhibition fo tumor progression and prolongation of survival
in a rodent glioma model. J Neurosurg 103:526-538, 2005.
Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman
FM, Chen TC, Schonthal AH. Multi-target
inhibition of drug-resistant multiple myeloma cell lines by
dimethyl-celecoxib(DMC), a non-COX-2 inhibitory analog of
celecoxib. Blood 106(13):4330-4338, December 2005
Charalambous C, Pen LB, Su YS, Milan J, Chen TC, Hofman FM.
Interleukin-8 Differentially Regulates
Migration of Tumor-Associated and Normal Human Brain Endothelial
Cells. Cancer Res 65(22): 10347-54, 2005
Wang J, Zhu N, Chua J, Swenson S, Costa FK, Schmitmeier S,
Sosnowski BA, Shichinohe T, Kasahara N, Chen TC. Retargeting
of adenoviral vector using basic fibroblast growth factor
ligand for malignant glioma gene therapy. J Neurosurg
103:1058–1066, 2005
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