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The Department of Neurosurgery is actively involved in basic science and clinical research. Below we have provided links to many of our recent publications.

Charalambous C, Hofman FM, Chen TC. Functional and phenotypic differences between glioblastoma-derived and normal human brain endothelial cells. J Neurosurg 102(4):699-705, 2005.

Schmitmeier S, Markland FS, Schonthal AH, Chen TC. Potent mimicry of fibronectin-induced signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin. Neurosurgery 57(1): 141-53, 2005.

Tai CK, Wang WJ, Chen TC, Kasahara N. Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma. Molecular Therapy 12: 842-851, 2005.

Khardosh A, Wang W, Chen TC, Schonthal A. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt’s lymphoma in vitro and in vivo, Cancer Biology & Therapy, 4(5):571-82, 2005.

Pyrko P, Wang W, Markland FS, Swenson SD, Schmitmeier S, Schonthal AH, Chen TC. The role of contortrostatin, a snake venom disintegrin, in the inhibition fo tumor progression and prolongation of survival in a rodent glioma model. J Neurosurg 103:526-538, 2005.

Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen TC, Schonthal AH. Multi-target inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib(DMC), a non-COX-2 inhibitory analog of celecoxib. Blood 106(13):4330-4338, December 2005

Charalambous C, Pen LB, Su YS, Milan J, Chen TC, Hofman FM. Interleukin-8 Differentially Regulates Migration of Tumor-Associated and Normal Human Brain Endothelial Cells. Cancer Res 65(22): 10347-54, 2005

Wang J, Zhu N, Chua J, Swenson S, Costa FK, Schmitmeier S, Sosnowski BA, Shichinohe T, Kasahara N, Chen TC. Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy. J Neurosurg 103:1058–1066, 2005

 

   
 
 



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